
Portrayed By Jennifer Love Hewitt
Melinda has the ability to see and communicate with ghosts. She moved to Grandview after she married Jim Clancy, a paramedic who knows of her ability. She had always been able to speak with the dead, or "earthbound spirits" as her grandmother (with whom she shared this ability) called them. Her mother, Beth Gordon, possesses the same gift, although she denies it. When Melinda was a little girl, her father was killed, thus showing that he never walked out on his family. Melinda also owns an Antique Store called "Same As It Never Was Antiques"

Portrayed By David Conrad
Jim Clancy is Melinda's husband. The character is portrayed by David Conrad. As a star of the series, he has appeared in all the episodes.
Jim and Melinda get married at the very start of the first season as well as move to Grandview. Jim had known of Melinda's unique abilities of being able to communicate with ghosts. Jim helped Melinda as much as he could, though Melinda's good friend Andrea Marino provided most of the aid.
In "Pilot", Dan Clancy appears to Melinda, but is not seen crossing over at the end of the episode.
On the five year anniversary of Jim's father's death in "On The Wings of a Dove", Jim begins acting strangely causing Melinda to think that Jim is being haunted by a malevolent spirit.
In "Friendly Neighborhood Ghost" Jim argues with Melinda about how her gift can sometimes cause things to go too far.
In, "Last Execution", Jim is sued for attempting to help a woman after an injury.
It is revealed in the Pilot that Jim witnessed his older brother, Dan, die when they were young kids. After having seen Dan die, and being unable to save him, Jim decides to become a paramedic.
Jim enjoyed camping and playing baseball with his father when he was younger.
Five years before the start of the show, Jim's father died.
Jim met Melinda when he rescued her from her burning apartment complex.
With the death of Melinda's close friend, Andrea, at the end of season one, Jim becomes a big supporter of what Melinda does to help the dead in season two.
The ghost of an old high school friend contacts him in the episode "The Woman of His Dreams", Melinda recommends Jim visit an occult professor from Rockland University, Rick Payne for help.
When Jim and Melinda go on their first camping trip in "A Vicious Cycle", it is interrupted by a ghost.
Jim, along with Rick and Melinda, break into Gabriel Lawrence's home, Gabriel is a fellow Ghost Whisperer though he supports the Dark Side, and learn of Gabriel's obsession with Melinda. Throughout the season, Jim's friend Tim Flaherty vies for Delia Banks's affections.
After Melinda's near death experience during the season two finale, "The Gathering", Jim becomes worried about what else could happen to Melinda due to the ghosts. Jim also helps try to find information about Melinda's father, Tom Gordon, who might or might not be dead, as well as try to find any information about Melinda's brother.
In "Haunted Hero", Jim and Melinda welcome a returning soldier from Iraq, Matt, back to Grandview. When Matt becomes so fully paranoid due to being haunted by his dead comrades and due to post-traumatic stress disorder, Jim confronts Matt in the town square and talks Matt out of trying to kill himself. Jim delivered some of his convincing argument with Matt's gun pointed at him.
In "Weight Of What Was", Gabriel returns to Grandview and Jim throws him away, though, not before Gabriel reveals that he is Melinda's half-brother. Jim, Rick, and Delia go in search of Melinda, who is trapped in old Grandview which is buried under present day Grandview. Tessa, the ghost of Melinda's ancestor from her mother's side who was also a Ghost Whisperer, helps them find Melinda by communicating with Delia and Jim.
Jim also begins thinking of moving out of Grandview while attending Medical School, at first Melinda does not like the idea but she later agrees to it. In "Deadbeat Dads" he admits that he would like to have children someday. He was also in fire fighting at some time

Portrayed By Aisha Tyler
Andrea Marino had once worked in New York, as a lawyer, until her job changed. She would move to Grandview and obtain a job working at "The Same As It Never Was", an antique store that is owned by Melinda. Andrea was a tall and single woman up until her death. She was played by Aisha Tyler, and was part of the main cast during season one.
Andrea becomes Melinda's best friend while working with her. Melinda even comes to trust Andrea enough to tell her about her gift of being able to communicate with earthbound spirits, or ghosts. Andrea becomes essential to the store and Melinda, because of the very fact that she knows about Melinda's gift. Such as, whenever Melinda has to run off and help a ghost, Andrea is left to keep the store. Andrea also helps Melinda with difficult cross overs removing some of the stress from Melinda's husband, Jim. In "The One" a plane crashes and Andrea notices Melinda is hiding something. She believes that her brother Mitch had died during the plane crash and that Melinda is seeing his ghost.
At the end of season one it was revealed that it was Andrea who had died during the crash and not Mitch. While Andrea was not on the plane she died because her car had been on the path that the plane had crashed on. Romano attempts to prevent Andrea from crossing over into the Light, and instead to join him on the Dark Side. Melinda would not allow such a horrific occurrence to happen to her friend and so she sets out to stop Romano and warn Andrea. With the help of an occult professor at Rockland University, Rick Payne, Melinda is able to help Andrea find peace and cross over into the Light.
Andrea is later mentioned in "Delia's First Ghost" and "The Prophet". Also, while having been successfully crossed over into the Light for over a year, two ghosts taunt Melinda by calling her Andrea during "Bad Blood".

Portrayed By Camryn Manheim
Delia Banks joined the main cast of Ghost Whisperer at the start of season 2. She and her teenage son, Ned, lost their husband and father Charlie three years prior to their appearance on the show. Delia became a real estate agent after Charlie's death. The character is portrayed by Camryn Manheim.
Delia meets Melinda Gordon after Melinda calls Delia about Ned having tried to shoplift from Melinda's antique store. Delia tells Melinda about how stressful her job as a real estate agent is, so Melinda offers her a job to help work at the antique store, which Delia accepts. They begin a friendship, though Delia does not know about Melinda's gift at first. In the episode "Delia's First Ghost" Melinda has to tell Delia about her gift because Charlie's spirit is haunting her. At first Delia calls Melinda crazy, admitting that she had seen Melinda talking to herself and was worried. Delia even goes as far as to tell Melinda not to expect her at work again. By the end of the episode Delia learns, with Melinda's help, that Charlie is only haunting her because he wants her to be safe. While still a little skeptical of Melinda's gift, Delia tells her that she will open the shop the next morning.
Delia remains skeptical concerning Melinda's gift in season three, but discusses the various ghosts that Melinda encounters to help Melinda with them. When Melinda was stalked by a lawyer, Shane, he tampered with Ned's records because Delia was trying to get him into private school. Nevertheless, when Shane was caught Ned's records were untarnished and Ned got in. In episode 5, "Weight of What Was" Delia travels along with Jim and Rick into a series of underground tunnels and alleyways from a much older Grandview to find Melinda. With the help of a ghost named Tessa helping Delia and Jim they manage to find Melinda and get her to safety. In "Bad Blood", Delia's need to find a rational explanation for every situation, including ones involving ghosts, is brought up. Delia tells Melinda that she will try to accept the notion of ghosts more.

Portrayed By Jay Mohr
Rick Payne becomes a professor at Rockland University and marries his wife, Kate. He and his wife live somewhere in Grandview, at some point Kate Payne dies. The character is portrayed by Jay Mohr.
At the beginning of season two, Melinda Gordon first seeks Rick Payne's help to save her deceased friend, Andrea Marino, who is being attacked by dark spirits. She finds him teaching an occult class at Rockland University. She continues to seek Rick's help for various paranormal occurrences throughout the rest of the season. Rick first meets Melinda's husband, Jim Clancy, when Melinda recommends Jim talk to him about a ghost. It is is "The Night We Met" that Rick first questions Melinda about whether or not she believes she has supernatural abilities, as well as meets Melinda's close friend and co-worker, Delia Banks. It is only in the episode "Cat's Claw", that Melinda finally informs Rick of her abilities. Come the season finale, Rick and Melinda are seen working very closely trying to figure out who Gabriel Lawrence, a dark Ghost Whisperer, really is. Rick, Jim, and Melinda go as far as breaking into Gabriel's home. It is also revealed that Rick's wife, Kate, is a ghost who works for the dark side.
The character joins the main cast in season three. Come the beginning of this season, Rick appears to be worried about Melinda after her near death experience. He also works a large deal more with Melinda on some things. In "The Weight of What Was", Rick, Jim, and Delia all travel into old Grandview to try and find Melinda. Jim and Delia are aided by a ghost named Tessa, who is an ancestor of Melinda's, to find the trapped Melinda. Rick also helps Melinda search town death records for information about Tessa, who at the time Melinda believed to be Gabriel's mother, though a group of ghosts attempt to stop them from finding anything. In "Double Exposure", Rick's date and co-worker, Claudia, is haunted by a ghost who makes it so she cannot appear in any pictures.
It seems Rick had somewhat of a crush on Melinda when they first met, clearly embarrassed by everything he said to her, afraid it might sound stupid. The crush went away after he met Jim, Melinda's husband. After, Melinda and Rick became close friends.